Screening of Anti-inflammatory Potential of Cissampelos Pareira Linn Leaves Extract in Albino Rats

Anti-inflammatory activity of the ethanolic extract of the Cissampelos pariera Linn leaves was studied in albino wistar rats using the carrageenan induced rat paw edema model. The ethanolic extract of Cissampelos pariera (400 mg/kg p.o.) inhibited carrageenan induced rat paw edema. The extract was also studied for its preliminary phytochemical screening and acute toxicity studies. The result indicated that the extract produced significant (P < 0.05) anti-inflammatory activity when compared with the standard drug indomethacin (10 mg/kg p. o.) and untreated control. INTRODUCTION: Cissampelos pariera Linn, belonging to the family Menispermacae, is commonly known as patha (Hindi). It used in the traditional system of medicine in the treatment of various diseases like dysentery, diarrhea and skin disorder. The leaf juice possesses antiseptic, insecticidal and parasiticidal properties, used to check hemorrhage from cuts burns and wounds